5X1W
PKM2 in complex with compound 5
Summary for 5X1W
Entry DOI | 10.2210/pdb5x1w/pdb |
Related | 5X1V |
Descriptor | Pyruvate kinase PKM, 1,6-di-O-phosphono-beta-D-fructofuranose, 4-[2,3-bis(chloranyl)phenyl]carbonyl-N-[2-[[4-[2,3-bis(chloranyl)phenyl]carbonyl-1-methyl-pyrrol-2-yl]carbonylamino]ethyl]-1-methyl-pyrrole-2-carboxamide, ... (4 entities in total) |
Functional Keywords | activator, complex, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 242801.49 |
Authors | Matsui, Y.,Hanzawa, H. (deposition date: 2017-01-27, release date: 2017-05-31, Last modification date: 2023-11-22) |
Primary citation | Matsui, Y.,Yasumatsu, I.,Asahi, T.,Kitamura, T.,Kanai, K.,Ubukata, O.,Hayasaka, H.,Takaishi, S.,Hanzawa, H.,Katakura, S. Discovery and structure-guided fragment-linking of 4-(2,3-dichlorobenzoyl)-1-methyl-pyrrole-2-carboxamide as a pyruvate kinase M2 activator Bioorg. Med. Chem., 25:3540-3546, 2017 Cited by PubMed: 28511909DOI: 10.1016/j.bmc.2017.05.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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