5WZX
Structural basis for a pentacyclic oleanane-type triterpenoid as a ligand of FXR
Summary for 5WZX
Entry DOI | 10.2210/pdb5wzx/pdb |
Descriptor | Bile acid receptor, SRC2-3 peptide from Nuclear receptor coactivator 2, (4aR,6aR,6aS,6bS,8aS,9R,12aR,14bR)-2,2,6a,6b,9,12a-hexamethyl-10-oxidanylidene-1,3,4,5,6,6a,7,8,8a,9,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid, ... (5 entities in total) |
Functional Keywords | fxr ligand, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1 Nucleus: Q15596 |
Total number of polymer chains | 4 |
Total formula weight | 57430.32 |
Authors | |
Primary citation | Lu, Y.,Zheng, W.,Lin, S.,Guo, F.,Zhu, Y.,Wei, Y.,Liu, X.,Jin, S.,Jin, L.,Li, Y. Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity Mol. Pharmacol., 93:63-72, 2018 Cited by PubMed: 29162643DOI: 10.1124/mol.117.109900 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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