5WYZ
Crystal structure of human TLR8 in complex with CU-CPT9b
Summary for 5WYZ
Entry DOI | 10.2210/pdb5wyz/pdb |
Related | 5WYX |
Descriptor | Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 191063.80 |
Authors | Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2017-01-16, release date: 2017-12-13, Last modification date: 2020-07-29) |
Primary citation | Zhang, S.,Hu, Z.,Tanji, H.,Jiang, S.,Das, N.,Li, J.,Sakaniwa, K.,Jin, J.,Bian, Y.,Ohto, U.,Shimizu, T.,Yin, H. Small-molecule inhibition of TLR8 through stabilization of its resting state Nat. Chem. Biol., 14:58-64, 2018 Cited by PubMed: 29155428DOI: 10.1038/nchembio.2518 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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