5WYZ

Crystal structure of human TLR8 in complex with CU-CPT9b

5WYZ の概要

• エントリーDOI: 10.2210/pdb5wyz/pdb
• 関連するPDBエントリー: 5WYX
• 分子名称: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: immune system
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 191063.80

構造登録者

Tanji, H.,Ohto, U.,Shimizu, T. (登録日: 2017-01-16, 公開日: 2017-12-13, 最終更新日: 2020-07-29)

• 主引用文献: Zhang, S.,Hu, Z.,Tanji, H.,Jiang, S.,Das, N.,Li, J.,Sakaniwa, K.,Jin, J.,Bian, Y.,Ohto, U.,Shimizu, T.,Yin, H.; Small-molecule inhibition of TLR8 through stabilization of its resting state; Nat. Chem. Biol., 14:58-64, 2018; PubMed: 29155428; DOI: 10.1038/nchembio.2518

実験手法

X-RAY DIFFRACTION (2.3 Å)