5WSB

Pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate, allosteric activators AMP and Glucose 6-Phosphate

5WSB の概要

• エントリーDOI: 10.2210/pdb5wsb/pdb
• 関連するPDBエントリー: 5WRP 5WS8 5WS9 5WSA 5WSC
• 分子名称: Pyruvate kinase, ADENOSINE MONOPHOSPHATE, 6-O-phosphono-alpha-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: pyruvate kinase, glycolysis, tetramer, allostery, synergism, phospho transferase, transferase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 207165.11

構造登録者

Zhong, W.,Cai, Q.,El Sahili, A.,Lescar, J.,Dedon, P.C. (登録日: 2016-12-06, 公開日: 2017-11-15, 最終更新日: 2023-11-08)

• 主引用文献: Zhong, W.,Cui, L.,Goh, B.C.,Cai, Q.,Ho, P.,Chionh, Y.H.,Yuan, M.,Sahili, A.E.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.,Lescar, J.,Dedon, P.C.; Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.; Nat Commun, 8:1986-1986, 2017; PubMed: 29215013; DOI: 10.1038/s41467-017-02086-y

実験手法

X-RAY DIFFRACTION (2.25 Å)