5WS8

Pyruvate kinase (PYK) from Mycobacterium tuberculosis in complex with Oxalate

Summary for 5WS8

• Entry DOI: 10.2210/pdb5ws8/pdb
• Related: 5WRP 5WS9 5WSA 5WSB 5WSC
• Descriptor: Pyruvate kinase, MAGNESIUM ION, OXALATE ION, ... (4 entities in total)
• Functional Keywords: pyruvate kinase, glycolysis, tetramer, allostery, synergism, phospho transferase, transferase
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 4
• Total formula weight: 204506.64

Authors

Zhong, W.,Cai, Q.,El Sahili, A.,Lescar, J.,Dedon, P.C. (deposition date: 2016-12-06, release date: 2017-11-15, Last modification date: 2023-11-08)

• Primary citation: Zhong, W.,Cui, L.,Goh, B.C.,Cai, Q.,Ho, P.,Chionh, Y.H.,Yuan, M.,Sahili, A.E.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.,Lescar, J.,Dedon, P.C.; Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.; Nat Commun, 8:1986-1986, 2017; PubMed: 29215013; DOI: 10.1038/s41467-017-02086-y

Experimental method

X-RAY DIFFRACTION (2.62 Å)