5WRO

Crystal structure of Drosophila enolase

5WRO の概要

• エントリーDOI: 10.2210/pdb5wro/pdb
• 分子名称: Enolase, CADMIUM ION, COBALT (II) ION, ... (7 entities in total)
• 機能のキーワード: enolase, hydrolyase, metabolism, lyase
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• 細胞内の位置: Cytoplasm: P15007
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48033.19

構造登録者

Zhang, Z.,Shi, Z. (登録日: 2016-12-02, 公開日: 2017-04-26, 最終更新日: 2024-10-09)

主引用文献

Sun, C.,Xu, B.,Liu, X.,Zhang, Z.,Su, Z.
Crystal structure of enolase from Drosophila melanogaster.
Acta Crystallogr F Struct Biol Commun, 73:228-234, 2017

PubMed Abstract: Enolase is an important enzyme in glycolysis and various biological processes. Its dysfunction is closely associated with diseases. Here, the enolase from Drosophila melanogaster (DmENO) was purified and crystallized. A crystal of DmENO diffracted to 2.0 Å resolution and belonged to space group R32. The structure was solved by molecular replacement. Like most enolases, DmENO forms a homodimer with conserved residues in the dimer interface. DmENO possesses an open conformation in this structure and contains conserved elements for catalytic activity. This work provides a structural basis for further functional and evolutionary studies of enolase.

PubMed: 28368282
DOI: 10.1107/S2053230X17004022

実験手法

X-RAY DIFFRACTION (2.015 Å)