5WRE
Hepatitis B virus core protein Y132A mutant in complex with heteroaryldihydropyrimidine (HAP_R01)
Summary for 5WRE
Entry DOI | 10.2210/pdb5wre/pdb |
Descriptor | Core protein, (2S)-1-[[(4R)-4-(2-chloranyl-4-fluoranyl-phenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-bis(fluoranyl)pyrrolidine-2-carboxylic acid, ISOPROPYL ALCOHOL, ... (6 entities in total) |
Functional Keywords | hepatitis b virus, hbv, core protein, capsid, y132a dimer, y132a hexamer, heteroaryldihydropyrimidine, hap, viral protein |
Biological source | Hepatitis B virus (HBV) |
Total number of polymer chains | 6 |
Total formula weight | 109090.51 |
Authors | |
Primary citation | Zhou, Z.,Hu, T.,Zhou, X.,Wildum, S.,Garcia-Alcalde, F.,Xu, Z.,Wu, D.,Mao, Y.,Tian, X.,Zhou, Y.,Shen, F.,Zhang, Z.,Tang, G.,Najera, I.,Yang, G.,Shen, H.C.,Young, J.A.,Qin, N. Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms. Sci Rep, 7:42374-42374, 2017 Cited by PubMed: 28205569DOI: 10.1038/srep42374 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.946 Å) |
Structure validation
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