5WRE

Hepatitis B virus core protein Y132A mutant in complex with heteroaryldihydropyrimidine (HAP_R01)

5WRE の概要

• エントリーDOI: 10.2210/pdb5wre/pdb
• 分子名称: Core protein, (2S)-1-[[(4R)-4-(2-chloranyl-4-fluoranyl-phenyl)-5-methoxycarbonyl-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-4,4-bis(fluoranyl)pyrrolidine-2-carboxylic acid, ISOPROPYL ALCOHOL, ... (6 entities in total)
• 機能のキーワード: hepatitis b virus, hbv, core protein, capsid, y132a dimer, y132a hexamer, heteroaryldihydropyrimidine, hap, viral protein
• 由来する生物種: Hepatitis B virus (HBV)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 109090.51

構造登録者

Zhou, Z.,Xu, Z.H. (登録日: 2016-12-01, 公開日: 2017-02-22, 最終更新日: 2023-11-08)

• 主引用文献: Zhou, Z.,Hu, T.,Zhou, X.,Wildum, S.,Garcia-Alcalde, F.,Xu, Z.,Wu, D.,Mao, Y.,Tian, X.,Zhou, Y.,Shen, F.,Zhang, Z.,Tang, G.,Najera, I.,Yang, G.,Shen, H.C.,Young, J.A.,Qin, N.; Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms.; Sci Rep, 7:42374-42374, 2017; PubMed: 28205569; DOI: 10.1038/srep42374

実験手法

X-RAY DIFFRACTION (1.946 Å)