5WP2
1.44 Angstrom crystal structure of CYP121 from Mycobacterium tuberculosis in complex with substrate and CN
Summary for 5WP2
Entry DOI | 10.2210/pdb5wp2/pdb |
Descriptor | Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, ... (6 entities in total) |
Functional Keywords | complex, p450, oxidoreductase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 1 |
Total formula weight | 44527.77 |
Authors | Fielding, A.,Dornevil, K.,Liu, A. (deposition date: 2017-08-03, release date: 2018-05-30, Last modification date: 2023-10-04) |
Primary citation | Fielding, A.J.,Dornevil, K.,Ma, L.,Davis, I.,Liu, A. Probing Ligand Exchange in the P450 Enzyme CYP121 from Mycobacterium tuberculosis: Dynamic Equilibrium of the Distal Heme Ligand as a Function of pH and Temperature. J. Am. Chem. Soc., 139:17484-17499, 2017 Cited by PubMed: 29090577DOI: 10.1021/jacs.7b08911 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.439 Å) |
Structure validation
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