5WOB

Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin

Replaces:  4Q5Z

Summary for 5WOB

DescriptorInsulin-degrading enzyme, Insulin, IDE-bound Fab heavy chain, ... (5 entities in total)
Functional Keywordshydrolase, complex
Biological sourceHomo sapiens (Human)
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Total number of polymer chains32
Total molecular weight1368634.8
Authors
McCord, L.A.,Liang, W.G.,Farcasanu, M.,Wang, A.G.,Koide, S.,Tang, W.J. (deposition date: 2017-08-01, release date: 2018-04-18, Last modification date: 2019-10-30)
Primary citation
Zhang, Z.,Liang, W.G.,Bailey, L.J.,Tan, Y.Z.,Wei, H.,Wang, A.,Farcasanu, M.,Woods, V.A.,McCord, L.A.,Lee, D.,Shang, W.,Deprez-Poulain, R.,Deprez, B.,Liu, D.R.,Koide, A.,Koide, S.,Kossiakoff, A.A.,Li, S.,Carragher, B.,Potter, C.S.,Tang, W.J.
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7:-, 2018
PubMed: 29596046 (PDB entries with the same primary citation)
DOI: 10.7554/eLife.33572
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.95 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.299600.2%5.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report