Crystal Structure Analysis of Fab1-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Insulin

Replaces:  4Q5Z

Summary for 5WOB

DescriptorInsulin-degrading enzyme, Insulin, IDE-bound Fab heavy chain, ... (5 entities in total)
Functional Keywordshydrolase, complex
Biological sourceHomo sapiens (Human)
Total number of polymer chains32
Total molecular weight1368634.8
McCord, L.A.,Liang, W.G.,Farcasanu, M.,Wang, A.G.,Koide, S.,Tang, W.J. (deposition date: 2017-08-01, release date: 2018-04-18, Last modification date: 2019-10-30)
Primary citation
Zhang, Z.,Liang, W.G.,Bailey, L.J.,Tan, Y.Z.,Wei, H.,Wang, A.,Farcasanu, M.,Woods, V.A.,McCord, L.A.,Lee, D.,Shang, W.,Deprez-Poulain, R.,Deprez, B.,Liu, D.R.,Koide, A.,Koide, S.,Kossiakoff, A.A.,Li, S.,Carragher, B.,Potter, C.S.,Tang, W.J.
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Elife, 7:-, 2018
PubMed: 29596046 (PDB entries with the same primary citation)
DOI: 10.7554/eLife.33572
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.299600.2%5.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report