5WNH
X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR
Summary for 5WNH
Entry DOI | 10.2210/pdb5wnh/pdb |
Related | 5WNE 5WNF 5WNG |
Descriptor | Rho-associated protein kinase 1, (2R)-N-(3-cyanophenyl)-2-{3-[(5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridin-2-yl)carbamoyl]phenyl}pyrrolidine-1-carboxamide (3 entities in total) |
Functional Keywords | rho kinase, kinase inhibitor, phosphorylation, transferase-inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 193995.50 |
Authors | |
Primary citation | Li, X.,Marshall, D.,Sibley, R.,Bosanac, T.,Ginn, J.,Kugler, S.,Gautschi, E.,Molinaro, T.,Soleymanzadeh, L.,Shih, C.K.,Young, E.R.R. Novel mechanism of Rho kinase selectivity: beyond the ATP pocket To Be Published, |
Experimental method |
Structure validation
Download full validation report