5WNG
X-RAY CO-STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE (ROCK1) WITH A HIGHLY SELECTIVE INHIBITOR
5WNG の概要
エントリーDOI | 10.2210/pdb5wng/pdb |
関連するPDBエントリー | 5WNE 5WNF 5WNH |
分子名称 | Rho-associated protein kinase 1, (2R)-N-(3-cyanophenyl)-2-(3-{[(6S)-6-(dimethylamino)-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl]carbamoyl}phenyl)pyrrolidine-1-carboxamide (3 entities in total) |
機能のキーワード | rho kinase, kinase inhibitor, phosphorylation, transferase-inhibitor complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 194107.71 |
構造登録者 | |
主引用文献 | Li, X.,Marshall, D.,Sibley, R.,Bosanac, T.,Ginn, J.,Kugler, S.,Gautschi, E.,Molinaro, T.,Soleymanzadeh, L.,Shih, C.K.,Young, E.R.R. Novel mechanism of Rho kinase selectivity: beyond the ATP pocket To Be Published, |
実験手法 | X-RAY DIFFRACTION (2.9 Å) |
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