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5WMT

Structure of GRP94 N-terminal Domain bound to resorcinylic inhibitor BnIm.

Summary for 5WMT
Entry DOI10.2210/pdb5wmt/pdb
Related5vyy
DescriptorEndoplasmin, 1,2-ETHANEDIOL, methyl 2-[2-(1-benzyl-1H-imidazol-2-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate, ... (5 entities in total)
Functional Keywordschaperone, inhibitor, complex, chaperone-inhibitor complex, chaperone/inhibitor
Biological sourceCanis lupus familiaris (Dog)
More
Total number of polymer chains4
Total formula weight108582.99
Authors
Que, N.S.,Gewirth, D.T. (deposition date: 2017-07-31, release date: 2018-04-18, Last modification date: 2023-10-04)
Primary citationQue, N.L.S.,Crowley, V.M.,Duerfeldt, A.S.,Zhao, J.,Kent, C.N.,Blagg, B.S.J.,Gewirth, D.T.
Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
J. Med. Chem., 61:2793-2805, 2018
Cited by
PubMed: 29528635
DOI: 10.1021/acs.jmedchem.7b01608
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.748 Å)
Structure validation

221051

건을2024-06-12부터공개중

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