5WMT
Structure of GRP94 N-terminal Domain bound to resorcinylic inhibitor BnIm.
Summary for 5WMT
Entry DOI | 10.2210/pdb5wmt/pdb |
Related | 5vyy |
Descriptor | Endoplasmin, 1,2-ETHANEDIOL, methyl 2-[2-(1-benzyl-1H-imidazol-2-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate, ... (5 entities in total) |
Functional Keywords | chaperone, inhibitor, complex, chaperone-inhibitor complex, chaperone/inhibitor |
Biological source | Canis lupus familiaris (Dog) More |
Total number of polymer chains | 4 |
Total formula weight | 108582.99 |
Authors | Que, N.S.,Gewirth, D.T. (deposition date: 2017-07-31, release date: 2018-04-18, Last modification date: 2023-10-04) |
Primary citation | Que, N.L.S.,Crowley, V.M.,Duerfeldt, A.S.,Zhao, J.,Kent, C.N.,Blagg, B.S.J.,Gewirth, D.T. Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding. J. Med. Chem., 61:2793-2805, 2018 Cited by PubMed: 29528635DOI: 10.1021/acs.jmedchem.7b01608 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.748 Å) |
Structure validation
Download full validation report