5WJ6
Crystal structure of glutaminase C in complex with inhibitor 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (UPGL-00004)
Summary for 5WJ6
Entry DOI | 10.2210/pdb5wj6/pdb |
Related | 5FI6 |
Descriptor | Glutaminase kidney isoform, mitochondrial, 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, ... (4 entities in total) |
Functional Keywords | glutaminase c, inhibitor, complex, glutamine, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 238773.42 |
Authors | Huang, Q.,Cerione, R.A. (deposition date: 2017-07-21, release date: 2018-01-10, Last modification date: 2023-10-04) |
Primary citation | Huang, Q.,Stalnecker, C.,Zhang, C.,McDermott, L.A.,Iyer, P.,O'Neill, J.,Reimer, S.,Cerione, R.A.,Katt, W.P. Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. J. Biol. Chem., 293:3535-3545, 2018 Cited by PubMed: 29317493DOI: 10.1074/jbc.M117.810101 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.445 Å) |
Structure validation
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