5WIV
Structure of the sodium-bound human D4 Dopamine receptor in complex with Nemonapride
Summary for 5WIV
Entry DOI | 10.2210/pdb5wiv/pdb |
Related | 5WIU |
Descriptor | D(4) dopamine receptor, soluble cytochrome b562 chimera, Nemonapride, PHOSPHATE ION, ... (7 entities in total) |
Functional Keywords | gpcr, dopamine receptor, antagonist, sodium, signaling protein-antagonist complex, signaling protein/antagonist |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 49407.12 |
Authors | Wacker, D.,Wang, S.,Levit, A.,Che, T.,Betz, R.M.,McCorvy, J.D.,Venkatakrishnan, A.J.,Huang, X.-P.,Dror, R.O.,Shoichet, B.K.,Roth, B.L. (deposition date: 2017-07-20, release date: 2017-10-18, Last modification date: 2023-10-04) |
Primary citation | Wang, S.,Wacker, D.,Levit, A.,Che, T.,Betz, R.M.,McCorvy, J.D.,Venkatakrishnan, A.J.,Huang, X.P.,Dror, R.O.,Shoichet, B.K.,Roth, B.L. D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science, 358:381-386, 2017 Cited by PubMed: 29051383DOI: 10.1126/science.aan5468 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.143 Å) |
Structure validation
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