Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5WIV

Structure of the sodium-bound human D4 Dopamine receptor in complex with Nemonapride

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004952	molecular_function	dopamine neurotransmitter receptor activity
A	0005506	molecular_function	iron ion binding
A	0005886	cellular_component	plasma membrane
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007195	biological_process	adenylate cyclase-inhibiting dopamine receptor signaling pathway
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue AQD A 1201

Chain	Residue
A	LEU111
A	HIS414
A	THR434
A	TYR438
A	HOH1321
A	ASP115
A	THR120
A	LEU187
A	VAL193
A	SER196
A	SER200
A	PHE410
A	PHE411

site_id	AC2
Number of Residues	6
Details	binding site for residue PO4 A 1202

Chain	Residue
A	TYR143
A	GLY148
A	SER149
A	ARG151
A	GLN152
A	PO41205

site_id	AC3
Number of Residues	3
Details	binding site for residue PO4 A 1203

Chain	Residue
A	GLN220
A	ARG390
A	ARG390

site_id	AC4
Number of Residues	3
Details	binding site for residue PO4 A 1204

Chain	Residue
A	LEU85
A	LEU85
A	LEU86

site_id	AC5
Number of Residues	4
Details	binding site for residue PO4 A 1205

Chain	Residue
A	PRO68
A	ARG133
A	ALA136
A	PO41202

site_id	AC6
Number of Residues	7
Details	binding site for residue PO4 A 1206

Chain	Residue
A	ALA1020
A	ALA1020
A	ASP1021
A	ASP1021
A	GLN1088
A	HOH1352
A	HOH1352

site_id	AC7
Number of Residues	4
Details	binding site for residue OLA A 1207

Chain	Residue
A	THR67
A	SER71
A	TRP160
A	PEG1222

site_id	AC8
Number of Residues	6
Details	binding site for residue OLA A 1208

Chain	Residue
A	GLN33
A	GLY40
A	ALA47
A	GLU95
A	SER431
A	TRP435

site_id	AC9
Number of Residues	7
Details	binding site for residue OLA A 1209

Chain	Residue
A	ASP132
A	ARG151
A	LEU155
A	TYR195
A	CYS199
A	OLA1212
A	HOH1332

site_id	AD1
Number of Residues	6
Details	binding site for residue OLA A 1210

Chain	Residue
A	LEU54
A	SER58
A	THR449
A	PHE455
A	ARG456
A	PHE459

site_id	AD2
Number of Residues	7
Details	binding site for residue OLA A 1211

Chain	Residue
A	LEU209
A	TYR212
A	PHE216
A	ARG390
A	PRO397
A	GLY401
A	OLA1213

site_id	AD3
Number of Residues	7
Details	binding site for residue OLA A 1212

Chain	Residue
A	ALA138
A	ASP191
A	VAL194
A	CYS199
A	OLA1209
A	PEG1216
A	HOH1324

site_id	AD4
Number of Residues	5
Details	binding site for residue OLA A 1213

Chain	Residue
A	PRO397
A	VAL398
A	ALA402
A	PHE451
A	OLA1211

site_id	AD5
Number of Residues	6
Details	binding site for residue OLA A 1214

Chain	Residue
A	PHE202
A	VAL412
A	THR416
A	LEU419
A	PRO426
A	GLU1081

site_id	AD6
Number of Residues	1
Details	binding site for residue PEG A 1215

Chain	Residue
A	HOH1302

site_id	AD7
Number of Residues	1
Details	binding site for residue PEG A 1216

Chain	Residue
A	OLA1212

site_id	AD8
Number of Residues	1
Details	binding site for residue PEG A 1217

Chain	Residue
A	MET114

site_id	AD9
Number of Residues	1
Details	binding site for residue PEG A 1218

Chain	Residue
A	PRO89

site_id	AE1
Number of Residues	1
Details	binding site for residue PEG A 1219

Chain	Residue
A	SER53

site_id	AE2
Number of Residues	4
Details	binding site for residue PEG A 1220

Chain	Residue
A	TYR93
A	LEU103
A	SER104
A	PEG1221

site_id	AE3
Number of Residues	3
Details	binding site for residue PEG A 1221

Chain	Residue
A	TYR93
A	SER104
A	PEG1220

site_id	AE4
Number of Residues	1
Details	binding site for residue PEG A 1222

Chain	Residue
A	OLA1207

site_id	AE5
Number of Residues	1
Details	binding site for residue PEG A 1223

Chain	Residue
A	ALA432

site_id	AE6
Number of Residues	5
Details	binding site for residue NA A 1224

Chain	Residue
A	SER122
A	SER441
A	HOH1349
A	HOH1357
A	ASP80

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIfNLCAISVDRFVaV

Chain	Residue	Details
A	ALA121-VAL137

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	13
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	40
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29051383","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"29051383","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	31
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"29051383","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"29051383","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"29051383","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"29051383","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"29051383","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"29051383","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	15
Details	Repeat: {"description":"1; approximate"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	15
Details	Repeat: {"description":"2"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	15
Details	Repeat: {"description":"3"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	16
Details	Compositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29051383","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29051383","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WIU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WIV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)