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5WIS

Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution

This is a non-PDB format compatible entry.
Summary for 5WIS
Entry DOI10.2210/pdb5wis/pdb
Descriptor23S ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
Functional Keywordsmacrolide, antibiotic, inhibitor, inhibition of translation, peptidyl transferase center, ribosome
Biological sourceEscherichia coli
More
Total number of polymer chains112
Total formula weight4572626.23
Authors
Almutairi, M.M.,Svetlov, M.S.,Hansen, D.A.,Khabibullina, N.F.,Klepacki, D.,Kang, H.Y.,Sherman, D.H.,Vazquez-Laslop, N.,Polikanov, Y.S.,Mankin, A.S. (deposition date: 2017-07-20, release date: 2018-02-14, Last modification date: 2023-11-15)
Primary citationAlmutairi, M.M.,Svetlov, M.S.,Hansen, D.A.,Khabibullina, N.F.,Klepacki, D.,Kang, H.Y.,Sherman, D.H.,Vazquez-Laslop, N.,Polikanov, Y.S.,Mankin, A.S.
Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.
Nucleic Acids Res., 45:9573-9582, 2017
Cited by
PubMed: 28934499
DOI: 10.1093/nar/gkx673
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.703 Å)
Structure validation

217705

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