5WIS

Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution

これはPDB形式変換不可エントリーです。

5WIS の概要

• エントリーDOI: 10.2210/pdb5wis/pdb
• 分子名称: 23S ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
• 機能のキーワード: macrolide, antibiotic, inhibitor, inhibition of translation, peptidyl transferase center, ribosome
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 112
• 化学式量合計: 4572626.23

構造登録者

Almutairi, M.M.,Svetlov, M.S.,Hansen, D.A.,Khabibullina, N.F.,Klepacki, D.,Kang, H.Y.,Sherman, D.H.,Vazquez-Laslop, N.,Polikanov, Y.S.,Mankin, A.S. (登録日: 2017-07-20, 公開日: 2018-02-14, 最終更新日: 2023-11-15)

• 主引用文献: Almutairi, M.M.,Svetlov, M.S.,Hansen, D.A.,Khabibullina, N.F.,Klepacki, D.,Kang, H.Y.,Sherman, D.H.,Vazquez-Laslop, N.,Polikanov, Y.S.,Mankin, A.S.; Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins.; Nucleic Acids Res., 45:9573-9582, 2017; PubMed: 28934499; DOI: 10.1093/nar/gkx673

実験手法

X-RAY DIFFRACTION (2.703 Å)