5WIJ
JAK2 Pseudokinase in complex with NU6140
Summary for 5WIJ
Entry DOI | 10.2210/pdb5wij/pdb |
Descriptor | Tyrosine-protein kinase JAK2, 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide (3 entities in total) |
Functional Keywords | jak2, pseudokinase, nu6140, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32103.89 |
Authors | |
Primary citation | McNally, R.,Li, Q.,Li, K.,Dekker, C.,Vangrevelinghe, E.,Jones, M.,Chene, P.,Machauer, R.,Radimerski, T.,Eck, M.J. Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain. ACS Chem. Biol., 14:587-593, 2019 Cited by PubMed: 30763067DOI: 10.1021/acschembio.8b00722 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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