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5WIJ

JAK2 Pseudokinase in complex with NU6140

Summary for 5WIJ
Entry DOI10.2210/pdb5wij/pdb
DescriptorTyrosine-protein kinase JAK2, 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide (3 entities in total)
Functional Keywordsjak2, pseudokinase, nu6140, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight32103.89
Authors
Li, Q.,Eck, M.J.,Li, K.,Park, E. (deposition date: 2017-07-19, release date: 2018-08-01, Last modification date: 2024-03-13)
Primary citationMcNally, R.,Li, Q.,Li, K.,Dekker, C.,Vangrevelinghe, E.,Jones, M.,Chene, P.,Machauer, R.,Radimerski, T.,Eck, M.J.
Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain.
ACS Chem. Biol., 14:587-593, 2019
Cited by
PubMed: 30763067
DOI: 10.1021/acschembio.8b00722
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.04 Å)
Structure validation

217705

数据于2024-03-27公开中

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