5WI5

2.0 Angstrom Resolution Crystal Structure of UDP-N-acetylglucosamine 1-carboxyvinyltransferase from Streptococcus pneumoniae in Complex with Uridine-diphosphate-2(n-acetylglucosaminyl) butyric acid, (2R)-2-(phosphonooxy)propanoic acid and Magnesium.

Summary for 5WI5

• Entry DOI: 10.2210/pdb5wi5/pdb
• Descriptor: UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1, (2R)-2-(phosphonooxy)propanoic acid, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: structural genomics, center for structural genomics of infectious diseases, csgid, udp-n-acetylglucosamine 1-carboxyvinyltransferase, uridine-diphosphate-2(n-acetylglucosaminyl) butyric acid, (2r)-2-(phosphonooxy)propanoic acid, magnesium, transferase
• Biological source: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
• Cellular location: Cytoplasm : Q97NQ4
• Total number of polymer chains: 4
• Total formula weight: 188263.14

Authors

Minasov, G.,Shuvalova, L.,Dubrovska, I.,Kiryukhina, O.,Grimshaw, S.,Kwon, K.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2017-07-18, release date: 2017-08-02, Last modification date: 2026-02-11)

Primary citation

Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F.
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc, 14:e0020025-e0020025, 2025

PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

PubMed: 40391899
DOI: 10.1128/mra.00200-25

Experimental method

X-RAY DIFFRACTION (2 Å)