5WH8

Cellulase Cel5C_n

Summary for 5WH8

• Entry DOI: 10.2210/pdb5wh8/pdb
• Descriptor: Putative carbohydrate-active enzyme, 1,2-ETHANEDIOL, PENTAETHYLENE GLYCOL, ... (5 entities in total)
• Functional Keywords: cellulase, gh5, hydrolase
• Biological source: uncultured organism
• Total number of polymer chains: 1
• Total formula weight: 38107.49

Authors

Koropatkin, N.M.,Pope, P.B.,Naas, A.E. (deposition date: 2017-07-15, release date: 2018-03-14, Last modification date: 2024-01-17)

Primary citation

Naas, A.E.,Solden, L.M.,Norbeck, A.D.,Brewer, H.,Hagen, L.H.,Heggenes, I.M.,McHardy, A.C.,Mackie, R.I.,Pasa-Tolic, L.,Arntzen, M.O.,Eijsink, V.G.H.,Koropatkin, N.M.,Hess, M.,Wrighton, K.C.,Pope, P.B.
"Candidatus Paraporphyromonas polyenzymogenes" encodes multi-modular cellulases linked to the type IX secretion system.
Microbiome, 6:44-44, 2018

PubMed Abstract: In nature, obligate herbivorous ruminants have a close symbiotic relationship with their gastrointestinal microbiome, which proficiently deconstructs plant biomass. Despite decades of research, lignocellulose degradation in the rumen has thus far been attributed to a limited number of culturable microorganisms. Here, we combine meta-omics and enzymology to identify and describe a novel Bacteroidetes family ("Candidatus MH11") composed entirely of uncultivated strains that are predominant in ruminants and only distantly related to previously characterized taxa.

PubMed: 29490697
DOI: 10.1186/s40168-018-0421-8

Experimental method

X-RAY DIFFRACTION (1.57 Å)