5WH6
Crystal structure of PDE4D2 in complex with inhibitor (S_Zl-n-91)
Summary for 5WH6
Entry DOI | 10.2210/pdb5wh6/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, 1-[4-(difluoromethoxy)-3-{[(3S)-oxolan-3-yl]oxy}phenyl]-3-methylbutan-1-one, ZINC ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, inhibitor zl-n-91, pde4d-s91 complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 116551.39 |
Authors | |
Primary citation | Feng, X.,Wang, H.,Ye, M.,Xu, X.T.,Xu, Y.,Yang, W.,Zhang, H.T.,Song, G.,Ke, H. Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors. Biochemistry, 57:4518-4525, 2018 Cited by PubMed: 29975048DOI: 10.1021/acs.biochem.8b00336 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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