5WGP

Human Carbonic Anhydrase IX-mimic complexed with AceK

Summary for 5WGP

Entry DOI	10.2210/pdb5wgp/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, Acesulfame, ... (4 entities in total)
Functional Keywords	carbonic anhydrase, acesulfame, inhibitor, lyase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29399.33
Authors	Murray, A.B.,Lomelino, C.L.,Supuran, C.T.,McKenna, R. (deposition date: 2017-07-14, release date: 2018-02-07, Last modification date: 2024-03-13)
Primary citation	Murray, A.B.,Lomelino, C.L.,Supuran, C.T.,McKenna, R. "Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms. J. Med. Chem., 61:1176-1181, 2018 Cited by PubMed: 29266943 DOI: 10.1021/acs.jmedchem.7b01470 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.53 Å)

Structure validation