5WGC

propionyl-DpsC in complex with oxetane-bearing probe

Summary for 5WGC

Entry DOI	10.2210/pdb5wgc/pdb
Descriptor	Daunorubicin-doxorubicin polyketide synthase, (3-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}oxetan-3-yl)acetic acid (3 entities in total)
Functional Keywords	enzyme-probe complex, transferase
Biological source	Streptomyces peucetius
Total number of polymer chains	2
Total formula weight	76139.81
Authors	Milligan, J.C.,Ellis, B.D.,White, A.R.,Vanderwal, C.D.,Tsai, S.C. (deposition date: 2017-07-13, release date: 2018-04-18, Last modification date: 2023-11-15)
Primary citation	Ellis, B.D.,Milligan, J.C.,White, A.R.,Duong, V.,Altman, P.X.,Mohammed, L.Y.,Crump, M.P.,Crosby, J.,Luo, R.,Vanderwal, C.D.,Tsai, S.C. An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase. J. Am. Chem. Soc., 140:4961-4964, 2018 Cited by PubMed: 29620883 DOI: 10.1021/jacs.7b11793 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation