5WG7
Human Carbonic Anhydrase II complexed with AceK
Summary for 5WG7
Entry DOI | 10.2210/pdb5wg7/pdb |
Descriptor | Carbonic anhydrase 2, Acesulfame, ZINC ION, ... (5 entities in total) |
Functional Keywords | carbonic anhydrase, acesulfame, inhibitor, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 30253.24 |
Authors | Murray, A.B.,Lomelino, C.L.,Supuran, C.T.,McKenna, R. (deposition date: 2017-07-13, release date: 2018-02-07, Last modification date: 2024-03-13) |
Primary citation | Murray, A.B.,Lomelino, C.L.,Supuran, C.T.,McKenna, R. "Seriously Sweet": Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms. J. Med. Chem., 61:1176-1181, 2018 Cited by PubMed: 29266943DOI: 10.1021/acs.jmedchem.7b01470 PDB entries with the same primary citation |
Experimental method |
Structure validation
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