5WG5

Human GRK2 in complex with Gbetagamma subunits and CCG224061

Summary for 5WG5

• Entry DOI: 10.2210/pdb5wg5/pdb
• Descriptor: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: beta-adrenergic receptor kinase 1 guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : P25098; Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63212
• Total number of polymer chains: 3
• Total formula weight: 125304.33

Authors

Bouley, R.,Tesmer, J.J.G. (deposition date: 2017-07-13, release date: 2017-12-27, Last modification date: 2023-10-04)

• Primary citation: Bouley, R.,Waldschmidt, H.V.,Cato, M.C.,Cannavo, A.,Song, J.,Cheung, J.Y.,Yao, X.Q.,Koch, W.J.,Larsen, S.D.,Tesmer, J.J.G.; Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.; Mol. Pharmacol., 92:707-717, 2017; PubMed: 29070696; DOI: 10.1124/mol.117.110130

Experimental method

X-RAY DIFFRACTION (3.1 Å)