5WG5

Human GRK2 in complex with Gbetagamma subunits and CCG224061

5WG5 の概要

• エントリーDOI: 10.2210/pdb5wg5/pdb
• 分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: beta-adrenergic receptor kinase 1 guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm : P25098; Cell membrane ; Lipid-anchor ; Cytoplasmic side : P63212
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 125304.33

構造登録者

Bouley, R.,Tesmer, J.J.G. (登録日: 2017-07-13, 公開日: 2017-12-27, 最終更新日: 2023-10-04)

• 主引用文献: Bouley, R.,Waldschmidt, H.V.,Cato, M.C.,Cannavo, A.,Song, J.,Cheung, J.Y.,Yao, X.Q.,Koch, W.J.,Larsen, S.D.,Tesmer, J.J.G.; Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.; Mol. Pharmacol., 92:707-717, 2017; PubMed: 29070696; DOI: 10.1124/mol.117.110130

実験手法

X-RAY DIFFRACTION (3.1 Å)