5WG1

Kelch domain of human Keap1 bound to mutant Nrf2 EAGE peptide

5WG1 の概要

• エントリーDOI: 10.2210/pdb5wg1/pdb
• 分子名称: Kelch-like ECH-associated protein 1, Nrf2 EAGE mutant peptide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: scaffold, peptide-bound, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 75012.54

構造登録者

Carolan, J.P.,Lynch, A.J.,Allen, K.N. (登録日: 2017-07-13, 公開日: 2018-09-19, 最終更新日: 2023-10-04)

• 主引用文献: Zhong, M.,Lynch, A.,Muellers, S.N.,Jehle, S.,Luo, L.,Hall, D.R.,Iwase, R.,Carolan, J.P.,Egbert, M.,Wakefield, A.,Streu, K.,Harvey, C.M.,Ortet, P.C.,Kozakov, D.,Vajda, S.,Allen, K.N.,Whitty, A.; Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2).; Biochemistry, 59:563-581, 2020; PubMed: 31851823; DOI: 10.1021/acs.biochem.9b00943

実験手法

X-RAY DIFFRACTION (2.021 Å)