Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5WFR

Ligand-bound Ras:SOS:Ras complex

Summary for 5WFR
Entry DOI10.2210/pdb5wfr/pdb
DescriptorGTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsras, sos, oncoprotein, protein-protein interaction, mapk, signaling protein
Biological sourceHomo sapiens (Human)
More
Cellular locationCell membrane. Isoform 2: Nucleus: P01112
Total number of polymer chains3
Total formula weight95295.20
Authors
Sun, Q.,Phan, J.,Burns, M.C.,Fesik, S.W. (deposition date: 2017-07-12, release date: 2018-05-23, Last modification date: 2023-10-04)
Primary citationBurns, M.C.,Howes, J.E.,Sun, Q.,Little, A.J.,Camper, D.V.,Abbott, J.R.,Phan, J.,Lee, T.,Waterson, A.G.,Rossanese, O.W.,Fesik, S.W.
High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Anal. Biochem., 548:44-52, 2018
Cited by
PubMed: 29444450
DOI: 10.1016/j.ab.2018.01.025
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.46 Å)
Structure validation

217705

건을2024-03-27부터공개중

PDB statisticsPDBj update infoContact PDBjnumon