5WFC

Humanized mutant of the Chaetomium thermophilum Polycomb Repressive Complex 2 bound to the inhibitor GSK343

5WFC の概要

• エントリーDOI: 10.2210/pdb5wfc/pdb
• 関連するPDBエントリー: 5WF7
• 分子名称: Polycomb Protein EED, Histone-lysine-N-methyltransferase EZH2, Polycomb protein SUZ12 chimera, Histone H3.1, ... (6 entities in total)
• 機能のキーワード: transferase, inhibitor, complex, epigenetics, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 175034.35

構造登録者

Bratkowski, M.A.,Liu, X. (登録日: 2017-07-11, 公開日: 2018-06-27, 最終更新日: 2023-10-04)

• 主引用文献: Bratkowski, M.,Yang, X.,Liu, X.; An Evolutionarily Conserved Structural Platform for PRC2 Inhibition by a Class of Ezh2 Inhibitors.; Sci Rep, 8:9092-9092, 2018; PubMed: 29904056; DOI: 10.1038/s41598-018-27175-w

実験手法

X-RAY DIFFRACTION (2.282 Å)