5WEU

Crystal Structure of H2-Dd with disulfide-linked 10mer peptide

Summary for 5WEU

Entry DOI	10.2210/pdb5weu/pdb
Related	5WER 5WES 5WET
Descriptor	H-2 class I histocompatibility antigen, D-D alpha chain, Beta-2-microglobulin, Envelope glycoprotein gp160, ... (5 entities in total)
Functional Keywords	antigen presentation, peptide editing, major histompatibility complex class i, mhc-i, tapbpr, h2-dd, h-2dd, tapasin, peptide loading complex, plc, immune response, immune system
Biological source	Mus musculus (Mouse) More
Cellular location	Membrane; Single-pass type I membrane protein: P01900 Secreted: P01887 Surface protein gp120: Virion membrane ; Peripheral membrane protein . Transmembrane protein gp41: Virion membrane ; Single-pass type I membrane protein : P03377
Total number of polymer chains	3
Total formula weight	45335.94
Authors	Jiang, J.S.,Natarajan, K.,Boyd, L.F.,Margulies, D.H. (deposition date: 2017-07-10, release date: 2017-10-18, Last modification date: 2023-10-04)
Primary citation	Jiang, J.,Natarajan, K.,Boyd, L.F.,Morozov, G.I.,Mage, M.G.,Margulies, D.H. Crystal structure of a TAPBPR-MHC I complex reveals the mechanism of peptide editing in antigen presentation. Science, 358:1064-1068, 2017 Cited by PubMed: 29025991 DOI: 10.1126/science.aao5154 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.584 Å)

Structure validation