5WE7

Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-29782

Summary for 5WE7

• Entry DOI: 10.2210/pdb5we7/pdb
• Related: 5W3I 5W44 5W73 5W7U 5W92 5W9G 5WA6 5WA7 5WAP 5WB3 5WCS 5WCT 5WDC 5WDN 5WDW
• Descriptor: Polymerase acidic protein, MANGANESE (II) ION, 2-{(2R)-1-[2-(4-chlorophenoxy)-2-methylpropanoyl]pyrrolidin-2-yl}-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid, ... (5 entities in total)
• Functional Keywords: virus, nuclease, transcription, cap-snatching, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus; More
• Total number of polymer chains: 1
• Total formula weight: 22635.95

Authors

Kumar, G.,White, S.W. (deposition date: 2017-07-07, release date: 2018-01-03, Last modification date: 2024-03-13)

• Primary citation: Kumar, G.,White, S.W.; Crystal structure of the influenza virus PA endonuclease in complex with an inhibitor - SRI-29782; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.12 Å)