5WDN

Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6d (SRI-29680)

Summary for 5WDN

• Entry DOI: 10.2210/pdb5wdn/pdb
• Related: 5W3I 5W44 5W73 5W7U 5W92 5W9G 5WA6 5WA7 5WAP 5WB3 5WCS 5WCT 5WDC
• Descriptor: Polymerase acidic protein, MANGANESE (II) ION, 5-hydroxy-6-oxo-2-[(2S)-1-(phenoxyacetyl)pyrrolidin-2-yl]-1,6-dihydropyrimidine-4-carboxylic acid, ... (4 entities in total)
• Functional Keywords: virus, nuclease, transcription, cap-snatching, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus; More
• Total number of polymer chains: 1
• Total formula weight: 22439.37

Authors

Kumar, G.,White, S.W. (deposition date: 2017-07-05, release date: 2018-01-03, Last modification date: 2024-03-13)

• Primary citation: Beylkin, D.,Kumar, G.,Zhou, W.,Park, J.,Jeevan, T.,Lagisetti, C.,Harfoot, R.,Webby, R.J.,White, S.W.,Webb, T.R.; Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease.; Sci Rep, 7:17139-17139, 2017; PubMed: 29215062; DOI: 10.1038/s41598-017-17419-6

Experimental method

X-RAY DIFFRACTION (2.1 Å)