5WBY

Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex

Summary for 5WBY

Entry DOI	10.2210/pdb5wby/pdb
Descriptor	Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Proline-rich AKT1 substrate 1 (3 entities in total)
Functional Keywords	wd40, pras40 beta, complex, transferase
Biological source	Homo sapiens (Human) More
Cellular location	Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P42345 Cytoplasm : Q9BVC4 Cytoplasm, cytosol : Q96B36
Total number of polymer chains	6
Total formula weight	362511.43
Authors	Pavletich, N.P.,Yang, H. (deposition date: 2017-06-29, release date: 2017-12-20, Last modification date: 2023-10-04)
Primary citation	Yang, H.,Jiang, X.,Li, B.,Yang, H.J.,Miller, M.,Yang, A.,Dhar, A.,Pavletich, N.P. Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552:368-373, 2017 Cited by PubMed: 29236692 DOI: 10.1038/nature25023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation