5WBY

Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (B, A)	Serine/threonine-protein kinase mTOR	polymer	1177	134865.5	2	UniProt (P42345) Pfam (PF02259) Pfam (PF08771) Pfam (PF00454) Pfam (PF02260)	Homo sapiens (Human)	FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1
2	B, D (D, C)	Target of rapamycin complex subunit LST8	polymer	328	36054.2	2	UniProt (Q9BVC4) Pfam (PF00400)	Homo sapiens (Human)	TORC subunit LST8,G protein beta subunit-like,Protein GbetaL,Mammalian lethal with SEC13 protein 8,mLST8
3	E, F (P, O)	Proline-rich AKT1 substrate 1	polymer	98	10336.0	2	UniProt (Q96B36) Pfam (PF15798)	Homo sapiens (Human)	40 kDa proline-rich AKT substrate

Sequence modifications

B, A: 1376 - 2549 (UniProt: P42345)

PDB	External Database	Details
Gly 1373	-	expression tag
Thr 1374	-	expression tag
Gly 1375	-	expression tag

D, C: 1 - 326 (UniProt: Q9BVC4)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag

P, O: 114 - 207 (UniProt: Q96B36)

PDB	External Database	Details
Gly 110	-	expression tag
Ser 111	-	expression tag
Gly 112	-	expression tag
Arg 113	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	362511.4
All*	Total formula weight	362511.4

*Water molecules are not included.