5WBE

COX-1:MOFEZOLAC COMPLEX STRUCTURE

Summary for 5WBE

• Entry DOI: 10.2210/pdb5wbe/pdb
• Related: 5U6X
• Descriptor: Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: cox-1, cyclooxygenase, peroxidase, prostaglandin, heme, mofezolac, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Ovis aries (Sheep)
• Total number of polymer chains: 2
• Total formula weight: 144186.36

Authors

Cingolani, G.,Panella, A.,Perrone, M.G.,Vitale, P.,Smith, W.L.,Scilimati, A. (deposition date: 2017-06-28, release date: 2017-07-26, Last modification date: 2023-10-04)

• Primary citation: Cingolani, G.,Panella, A.,Perrone, M.G.,Vitale, P.,Di Mauro, G.,Fortuna, C.G.,Armen, R.S.,Ferorelli, S.,Smith, W.L.,Scilimati, A.; Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).; Eur J Med Chem, 138:661-668, 2017; PubMed: 28710965; DOI: 10.1016/j.ejmech.2017.06.045

Experimental method

X-RAY DIFFRACTION (2.75 Å)