5WB8

Crystal structure of the epidermal growth factor receptor extracellular region in complex with epigen

5WB8 の概要

• エントリーDOI: 10.2210/pdb5wb8/pdb
• 分子名称: Epidermal growth factor receptor, Epigen, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: receptor tyrosine kinase, growth factor, signaling, membrane protein, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 129970.76

構造登録者

Bessman, N.J.,Freed, D.M.,Moore, J.O.,Ferguson, K.M.,Lemmon, M.A. (登録日: 2017-06-28, 公開日: 2017-10-18, 最終更新日: 2023-10-04)

• 主引用文献: Freed, D.M.,Bessman, N.J.,Kiyatkin, A.,Salazar-Cavazos, E.,Byrne, P.O.,Moore, J.O.,Valley, C.C.,Ferguson, K.M.,Leahy, D.J.,Lidke, D.S.,Lemmon, M.A.; EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.; Cell, 171:683-695.e18, 2017; PubMed: 28988771; DOI: 10.1016/j.cell.2017.09.017

実験手法

X-RAY DIFFRACTION (3 Å)