5W7R

Crystal structure of OxaC in complex with SAH and oxaline

Summary for 5W7R

• Entry DOI: 10.2210/pdb5w7r/pdb
• Related: 5W7P
• Descriptor: OxaC, (3E,7aR,12aS)-3-[(1H-imidazol-4-yl)methylidene]-6,12-dimethoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydro-1H,5H-imidazo[1 ',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• Functional Keywords: methyltransferase, penicillium oxalicum, oxaline, indole alkaloid, transferase
• Biological source: Penicillium oxalicum
• Total number of polymer chains: 1
• Total formula weight: 48116.62

Authors

Newmister, S.A.,Romminger, S.,Schmidt, J.J.,Williams, R.M.,Smith, J.L.,Berlinck, R.G.S.,Sherman, D.H. (deposition date: 2017-06-20, release date: 2018-07-04, Last modification date: 2023-10-04)

• Primary citation: Newmister, S.A.,Romminger, S.,Schmidt, J.J.,Williams, R.M.,Smith, J.L.,Berlinck, R.G.S.,Sherman, D.H.; Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway.; Org. Biomol. Chem., 16:6450-6459, 2018; PubMed: 30141817; DOI: 10.1039/c8ob01565a

Experimental method

X-RAY DIFFRACTION (2.497 Å)