5W77

Solution structure of the MYC G-quadruplex bound to small molecule DC-34

5W77 の概要

• エントリーDOI: 10.2210/pdb5w77/pdb
• NMR情報: BMRB: 27144
• 分子名称: DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), POTASSIUM ION, 4-[(azepan-1-yl)methyl]-5-hydroxy-2-methyl-N-[4-(trifluoromethyl)phenyl]-1-benzofuran-3-carboxamide (3 entities in total)
• 機能のキーワード: c-myc promoter dna-inhibitor complex, c-myc promoter g-quadruplex, dna, dna-inhibitor complex, dna/inhibitor
• 由来する生物種: Homo sapiens
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7979.63

構造登録者

Chen, X.,Walters, K.J. (登録日: 2017-06-19, 公開日: 2018-10-24, 最終更新日: 2024-05-15)

• 主引用文献: Calabrese, D.R.,Chen, X.,Leon, E.C.,Gaikwad, S.M.,Phyo, Z.,Hewitt, W.M.,Alden, S.,Hilimire, T.A.,He, F.,Michalowski, A.M.,Simmons, J.K.,Saunders, L.B.,Zhang, S.,Connors, D.,Walters, K.J.,Mock, B.A.,Schneekloth Jr., J.S.; Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex.; Nat Commun, 9:4229-4229, 2018; PubMed: 30315240; DOI: 10.1038/s41467-018-06315-w

実験手法

SOLUTION NMR