5W6E

PDE1b complexed with compound 3S

5W6E の概要

• エントリーDOI: 10.2210/pdb5w6e/pdb
• 分子名称: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: phosphodiesterase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42552.04

構造登録者

Vajdos, F.F. (登録日: 2017-06-16, 公開日: 2018-05-30, 最終更新日: 2024-03-13)

• 主引用文献: Humphrey, J.M.,Movsesian, M.,Am Ende, C.W.,Becker, S.L.,Chappie, T.A.,Jenkinson, S.,Liras, J.L.,Liras, S.,Orozco, C.,Pandit, J.,Vajdos, F.F.,Vandeput, F.,Yang, E.,Menniti, F.S.; Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.; J. Med. Chem., 61:4635-4640, 2018; PubMed: 29718668; DOI: 10.1021/acs.jmedchem.8b00374

実験手法

X-RAY DIFFRACTION (1.9 Å)