5W5N

Crystal structure of human IgG4-Sigma2 Fc fragment

Summary for 5W5N

• Entry DOI: 10.2210/pdb5w5n/pdb
• Descriptor: Immunoglobulin heavy constant gamma 4, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: fc, immunoglobulin fold, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 53294.31

Authors

Armstrong, A.A.,Gilliland, G.L. (deposition date: 2017-06-15, release date: 2017-09-13, Last modification date: 2020-07-29)

• Primary citation: Tam, S.H.,McCarthy, S.G.,Armstrong, A.A.,Somani, S.,Wu, S.J.,Liu, X.,Gervais, A.,Ernst, R.,Saro, D.,Decker, R.,Luo, J.,Gilliland, G.L.,Chiu, M.L.,Scallon, B.J.; Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality.; Antibodies, 6:-, 2017; PubMed: 31548527; DOI: 10.3390/antib6030012

Experimental method

X-RAY DIFFRACTION (1.85 Å)