5W5C

Crystal structure of the primed SNARE-Complexin-Synaptotagmin-1 C2AB complex

Summary for 5W5C

Entry DOI	10.2210/pdb5w5c/pdb
Descriptor	Vesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ... (9 entities in total)
Functional Keywords	prefusion primed complex, neuronal exocytosis, synaptotagmin, snare complex, complexin, synchronous neurotransmitter release, exocytosis
Biological source	Rattus norvegicus (Rat) More
Cellular location	Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein: P63045 P32851 Cytoplasm, perinuclear region : P60881 P60881 Cytoplasm, cytosol : P63041 Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein : P21707
Total number of polymer chains	6
Total formula weight	71517.65
Authors	Zhou, Q.,Brunger, A.T. (deposition date: 2017-06-14, release date: 2017-08-23, Last modification date: 2023-10-04)
Primary citation	Zhou, Q.,Zhou, P.,Wang, A.L.,Wu, D.,Zhao, M.,Sudhof, T.C.,Brunger, A.T. The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. Nature, 548:420-425, 2017 Cited by PubMed: 28813412 DOI: 10.1038/nature23484 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation