5W5C

Crystal structure of the primed SNARE-Complexin-Synaptotagmin-1 C2AB complex

5W5C の概要

• エントリーDOI: 10.2210/pdb5w5c/pdb
• 分子名称: Vesicle-associated membrane protein 2, Syntaxin-1A, Synaptosomal-associated protein 25, ... (9 entities in total)
• 機能のキーワード: prefusion primed complex, neuronal exocytosis, synaptotagmin, snare complex, complexin, synchronous neurotransmitter release, exocytosis
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• 細胞内の位置: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein: P63045 P32851; Cytoplasm, perinuclear region : P60881 P60881; Cytoplasm, cytosol : P63041; Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein : P21707
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 71517.65

構造登録者

Zhou, Q.,Brunger, A.T. (登録日: 2017-06-14, 公開日: 2017-08-23, 最終更新日: 2023-10-04)

• 主引用文献: Zhou, Q.,Zhou, P.,Wang, A.L.,Wu, D.,Zhao, M.,Sudhof, T.C.,Brunger, A.T.; The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.; Nature, 548:420-425, 2017; PubMed: 28813412; DOI: 10.1038/nature23484

実験手法

X-RAY DIFFRACTION (1.85 Å)