5W55
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG048
Summary for 5W55
Entry DOI | 10.2210/pdb5w55/pdb |
Descriptor | Bromodomain-containing protein 4, 11-ethyl-2-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-5-methyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15716.07 |
Authors | Xu, X.,Blacklow, S.C. (deposition date: 2017-06-14, release date: 2018-06-20, Last modification date: 2023-10-04) |
Primary citation | Xu, X.,Blacklow, S.C. Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG048 To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.354 Å) |
Structure validation
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