5W4L

Crystal structure of the non-neutralizing and ADCC-potent C11-like antibody N12-i3 in complex with HIV-1 clade A/E gp120, the CD4 mimetic M48U1, and the antibody N5-i5.

Summary for 5W4L

• Entry DOI: 10.2210/pdb5w4l/pdb
• Related: 4H8W 4JZW
• Related PRD ID: PRD_001094
• Descriptor: clade A/E 93TH057 HIV-1 gp120 core, CD4 mimetic peptide M48U1, Antibody N5-i5 Fab heavy chain, ... (9 entities in total)
• Functional Keywords: hiv-1 gp120, clade a/e 93th057, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 285301.18

Authors

Tolbert, W.D.,Gohain, N.,Pazgier, M. (deposition date: 2017-06-12, release date: 2017-11-15, Last modification date: 2023-11-15)

• Primary citation: Tolbert, W.D.,Gohain, N.,Alsahafi, N.,Van, V.,Orlandi, C.,Ding, S.,Martin, L.,Finzi, A.,Lewis, G.K.,Ray, K.,Pazgier, M.; Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region.; Structure, 25:1719-1731.e4, 2017; PubMed: 29056481; DOI: 10.1016/j.str.2017.09.009

Experimental method

X-RAY DIFFRACTION (2.92 Å)