5W4K
Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution
This is a non-PDB format compatible entry.
Summary for 5W4K
Entry DOI | 10.2210/pdb5w4k/pdb |
Related PRD ID | PRD_002277 |
Descriptor | 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (63 entities in total) |
Functional Keywords | klebsazolicin, antibiotic, ripps, ribosome inhibitor, 70s ribosome, inhibition of translation, peptidyl transferase center, nascent peptide exit tunnel, ribosome-antibiotic complex, ribosome/antibiotic |
Biological source | Escherichia coli More |
Total number of polymer chains | 114 |
Total formula weight | 4576710.22 |
Authors | Metelev, M.,Osterman, I.A.,Ghilarov, D.,Khabibullina, N.F.,Yakimov, A.,Shabalin, K.,Utkina, I.,Travin, D.Y.,Komarova, E.S.,Serebryakova, M.,Artamonova, T.,Khodorkovskii, M.,Konevega, A.L.,Sergiev, P.V.,Severinov, K.,Polikanov, Y.S. (deposition date: 2017-06-12, release date: 2017-08-30, Last modification date: 2019-12-04) |
Primary citation | Metelev, M.,Osterman, I.A.,Ghilarov, D.,Khabibullina, N.F.,Yakimov, A.,Shabalin, K.,Utkina, I.,Travin, D.Y.,Komarova, E.S.,Serebryakova, M.,Artamonova, T.,Khodorkovskii, M.,Konevega, A.L.,Sergiev, P.V.,Severinov, K.,Polikanov, Y.S. Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel. Nat. Chem. Biol., 13:1129-1136, 2017 Cited by PubMed: 28846667DOI: 10.1038/nchembio.2462 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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