5W3P

ANTIBODY C706 IN COMPLEX WTH BETA-AMYLOID PEPTIDE 1-16

5W3P の概要

• エントリーDOI: 10.2210/pdb5w3p/pdb
• 関連するPDBエントリー: 3mcl
• 分子名称: Antibody C706 Fab LIGHT CHAIN, Antibody C706 Fab HEAVY CHAIN, Amyloid beta A4 protein, ... (6 entities in total)
• 機能のキーワード: immune system
• 由来する生物種: Mus musculus; 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P05067
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 49074.28

構造登録者

Teplyakov, A.,Obmolova, G.,Gilliland, G.L. (登録日: 2017-06-08, 公開日: 2017-09-20, 最終更新日: 2024-10-16)

主引用文献

Teplyakov, A.,Obmolova, G.,Gilliland, G.L.
A coiled conformation of amyloid-beta recognized by antibody C706.
Alzheimers Res Ther, 9:66-66, 2017

PubMed Abstract: β-Amyloid (Aβ) peptide is believed to play a pivotal role in the development of Alzheimer's disease. Passive immunization with anti-Aβ monoclonal antibodies may facilitate the clearance of Aβ in the brain and may thus prevent the downstream pathology. Antibodies targeting the immunodominant N-terminal epitope of Aβ and capable of binding both the plaques and soluble species have been most efficacious in animal models. Structural studies of such antibodies with bound Aβ peptides provided the basis for understanding the mechanisms of action and the differences in potency. To gain further insight into the structural determinants of antigen recognition and the preferential Aβ conformations, we determined the crystal structure of murine antibody C706 in complex with the N-terminal Aβ 1-16 peptide sequence.

PubMed: 28830506
DOI: 10.1186/s13195-017-0296-0

実験手法

X-RAY DIFFRACTION (1.92 Å)