5W2Y

INFLUENZA VIRUS NEURAMINIDASE N9 IN COMPLEX WITH 9-DEOXYGENATED 2,3-DIFLUORO-N-ACETYLNEURAMINIC ACID

Summary for 5W2Y

• Entry DOI: 10.2210/pdb5w2y/pdb
• Related: 5W26 5W2U 5W2W
• Descriptor: Neuraminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: influenza virus neuraminidase, n9, complex, 2, 3-difluorosialic acid, second binding site, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus (strain A/Tern/Australia/G70C/1975 H11N9)
• Cellular location: Virion membrane : P03472
• Total number of polymer chains: 1
• Total formula weight: 46869.59

Authors

Streltsov, V.A.,Mckimm-Breschkin, J.,Barrett, S.,Pilling, P.,Hader, S.,Watt, A.G. (deposition date: 2017-06-07, release date: 2018-02-21, Last modification date: 2023-10-04)

• Primary citation: McKimm-Breschkin, J.L.,Barrett, S.,Pilling, P.A.,Hader, S.,Watts, A.G.,Streltsov, V.A.; Structural and Functional Analysis of Anti-Influenza Activity of 4-, 7-, 8- and 9-Deoxygenated 2,3-Difluoro- N-acetylneuraminic Acid Derivatives.; J. Med. Chem., 61:1921-1933, 2018; PubMed: 29397718; DOI: 10.1021/acs.jmedchem.7b01467

Experimental method

X-RAY DIFFRACTION (2.39 Å)