5W2A

Structure of human DNA polymerase kappa in complex with Lucidin-derived DNA adduct and incoming dCMPNPP

Summary for 5W2A

• Entry DOI: 10.2210/pdb5w2a/pdb
• Related: 5W2C
• Descriptor: DNA polymerase kappa, DNA (5'-D(P*GP*CP*GP*GP*AP*TP*CP*AP*G)-3'), DNA (5'-D(*AP*TP*GP*(LDG)P*CP*TP*GP*AP*TP*CP*CP*GP*C)-3'), ... (8 entities in total)
• Functional Keywords: translesion synthesis, lucidin-derived dna adduct, dna polymerase kappa, mutagenesis, replication
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q9UBT6
• Total number of polymer chains: 6
• Total formula weight: 142281.22

Authors

Jha, V.K.,Ling, H. (deposition date: 2017-06-06, release date: 2017-10-18, Last modification date: 2024-03-13)

• Primary citation: Yockey, O.P.,Jha, V.,Ghodke, P.P.,Xu, T.,Xu, W.,Ling, H.,Pradeepkumar, P.I.,Zhao, L.; Mechanism of Error-Free DNA Replication Past Lucidin-Derived DNA Damage by Human DNA Polymerase kappa.; Chem. Res. Toxicol., 30:2023-2032, 2017; PubMed: 28972744; DOI: 10.1021/acs.chemrestox.7b00227

Experimental method

X-RAY DIFFRACTION (2.9 Å)